Characterization of an adduct between CC-1065 and a defined oligodeoxynucleotide duplex.

CC-1065 is a potent antitumor antibiotic produced by Streptomyces zelensis. The drug binds covalently through N-3 of adenine and lies within the minor groove of DNA. Previous studies indicated that CC-1065 reacted with adenine in DNA to yield a thermally labile product that could be used to reveal i...

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Publicat a:Nucleic Acids Res
Autors principals: Needham-VanDevanter, D R, Hurley, L H, Reynolds, V L, Theriault, N Y, Krueger, W C, Wierenga, W
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 1984
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC320064/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6473105/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/12.15.6159
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