Characterization of an adduct between CC-1065 and a defined oligodeoxynucleotide duplex.

CC-1065 is a potent antitumor antibiotic produced by Streptomyces zelensis. The drug binds covalently through N-3 of adenine and lies within the minor groove of DNA. Previous studies indicated that CC-1065 reacted with adenine in DNA to yield a thermally labile product that could be used to reveal i...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Needham-VanDevanter, D R, Hurley, L H, Reynolds, V L, Theriault, N Y, Krueger, W C, Wierenga, W
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 1984
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC320064/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6473105/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/12.15.6159
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