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Characterization of an adduct between CC-1065 and a defined oligodeoxynucleotide duplex.
CC-1065 is a potent antitumor antibiotic produced by Streptomyces zelensis. The drug binds covalently through N-3 of adenine and lies within the minor groove of DNA. Previous studies indicated that CC-1065 reacted with adenine in DNA to yield a thermally labile product that could be used to reveal i...
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| Publicado no: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
1984
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| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC320064/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6473105/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/12.15.6159 |
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