Development of a diphtheria toxin based anti-porcine CD3 recombinant immunotoxin

Anti-CD3 immunotoxins, which induce profound but transient T cell depletion in vivo by inhibiting eukaryotic protein synthesis in CD3+ cells, are effective reagents in large animal models of transplantation tolerance and autoimmune disease therapy. A diphtheria toxin based anti-porcine CD3 recombina...

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Main Authors: Wang, Zhirui, Duran-Struuck, Raimon, Crepeau, Rebecca, Matar, Abraham, Hanekamp, Isabel, Srinivasan, Srimathi, Neville, David M., Sachs, David H., Huang, Christene A.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3200572/
https://ncbi.nlm.nih.gov/pubmed/21866954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc200230h
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