Positive GABA(A) Receptor Modulators from Acorus calamus and Structural Analysis of (+)-Dioxosarcoguaiacol by 1D and 2D NMR and Molecular Modeling

[Image: see text] In a two-microelectrode voltage clamp with Xenopus laevis oocytes, a petroleum ether extract of Acorus calamus rhizomes enhanced the GABA-induced chloride current through GABA(A) receptors of the α(1)β(2)γ(2S) subtype by 277% ± 9.7% (100 μg/mL). β-Asarone (1), (+)-dioxosarcoguaiaco...

Full description

Saved in:
Bibliographic Details
Main Authors: Zaugg, Janine, Eickmeier, Eva, Ebrahimi, Samad Nejad, Baburin, Igor, Hering, Steffen, Hamburger, Matthias
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199944/
https://ncbi.nlm.nih.gov/pubmed/21563811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np200181d
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items