SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity

Members of sirtuin family regulate multiple critical biological processes, yet their role in carcinogenesis remains controversial. To investigate the physiological functions of SIRT2 in development and tumorigenesis, we disrupted Sirt2 in mice. We demonstrated that SIRT2 regulates the anaphase-promo...

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Detalhes bibliográficos
Main Authors: Kim, Hyun-Seok, Vassilopoulos, Athanassios, Wang, Rui-Hong, Lahusen, Tyler, Xiao, Zhen, Xu, Xiaoling, Li, Cuiling, Veenstra, Timothy D., Li, Bing, Yu, Hongtao, Ji, Junfang, Wang, Xin Wei, Park, Seong-Hoon, Cha, Yong I., Gius, David, Deng, Chu-Xia
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199577/
https://ncbi.nlm.nih.gov/pubmed/22014574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.09.004
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