SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity

Members of sirtuin family regulate multiple critical biological processes, yet their role in carcinogenesis remains controversial. To investigate the physiological functions of SIRT2 in development and tumorigenesis, we disrupted Sirt2 in mice. We demonstrated that SIRT2 regulates the anaphase-promo...

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Bibliografiske detaljer
Main Authors: Kim, Hyun-Seok, Vassilopoulos, Athanassios, Wang, Rui-Hong, Lahusen, Tyler, Xiao, Zhen, Xu, Xiaoling, Li, Cuiling, Veenstra, Timothy D., Li, Bing, Yu, Hongtao, Ji, Junfang, Wang, Xin Wei, Park, Seong-Hoon, Cha, Yong I., Gius, David, Deng, Chu-Xia
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199577/
https://ncbi.nlm.nih.gov/pubmed/22014574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.09.004
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