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WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis
The tyrosine kinase WEE1 controls the timing of entry into mitosis in eukaryotes and its genetic deletion leads to pre-implantation lethality in mice. Here, we show that besides the premature mitotic entry phenotype, Wee1 mutant murine cells fail to complete mitosis properly and exhibit several addi...
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| Publicado no: | Oncogene |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5547996/ https://ncbi.nlm.nih.gov/pubmed/25088202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.239 |
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