p53-independent Epigenetic Repression of the p21(WAF1) Gene in T-cell Acute Lymphoblastic Leukemia

The p53 protein is a primary mediator of cellular apoptosis and growth arrest after exposure to DNA-damaging agents. Previous work has shown that the majority of childhood acute lymphoblastic leukemia (ALL) cases express a wild type p53 gene, although the functionality of the p53 pathway has rarely...

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Bibliografiske detaljer
Main Authors: Davies, Carwyn, Hogarth, Linda A., Dietrich, Philipp A., Bachmann, Petra S., Mackenzie, Karen L., Hall, Andrew G., Lock, Richard B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199508/
https://ncbi.nlm.nih.gov/pubmed/21903579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.272336
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