BRI2 Protein Regulates β-Amyloid Degradation by Increasing Levels of Secreted Insulin-degrading Enzyme (IDE)

The amyloid precursor protein (APP) is one of the major proteins involved in Alzheimer disease (AD). Proteolytic cleavage of APP gives rise to amyloid-β (Aβ) peptides that aggregate and deposit extensively in the brain of AD patients. Although the increase in levels of aberrantly folded Aβ peptide i...

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Главные авторы: Kilger, Ellen, Buehler, Anika, Woelfing, Heidrun, Kumar, Sathish, Kaeser, Stephan A., Nagarathinam, Amudha, Walter, Jochen, Jucker, Mathias, Coomaraswamy, Janaky
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2011
Предметы:
Molecular Bases of Disease
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199491/
https://ncbi.nlm.nih.gov/pubmed/21873424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.288373
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