Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease

Familial Danish dementia (FDD) is a progressive neurodegenerative disease with cerebral deposition of Dan-amyloid (ADan), neuroinflammation, and neurofibrillary tangles, hallmark characteristics remarkably similar to those in Alzheimer's disease (AD). We have generated transgenic (tg) mouse mod...

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Bibliografiska uppgifter
Huvudupphovsmän: Coomaraswamy, Janaky, Kilger, Ellen, Wölfing, Heidrun, Schäfer, Claudia, Kaeser, Stephan A., Wegenast-Braun, Bettina M., Hefendehl, Jasmin K., Wolburg, Hartwig, Mazzella, Matthew, Ghiso, Jorge, Goedert, Michel, Akiyama, Haruhiko, Garcia-Sierra, Francisco, Wolfer, David P., Mathews, Paul M., Jucker, Mathias
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2010
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867864/
https://ncbi.nlm.nih.gov/pubmed/20385796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1001056107
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