Aβ42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

We have generated a novel transgenic mouse model on a C57BL/6J genetic background that coexpresses KM670/671NL mutated amyloid precursor protein and L166P mutated presenilin 1 under the control of a neuron-specific Thy1 promoter element (APPPS1 mice). Cerebral amyloidosis starts at 6–8 weeks and the...

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Detalhes bibliográficos
Main Authors: Radde, Rebecca, Bolmont, Tristan, Kaeser, Stephan A, Coomaraswamy, Janaky, Lindau, Dennis, Stoltze, Lars, Calhoun, Michael E, Jäggi, Fabienne, Wolburg, Hartwig, Gengler, Simon, Haass, Christian, Ghetti, Bernardino, Czech, Christian, Hölscher, Christian, Mathews, Paul M, Jucker, Mathias
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Scientific Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1559665/
https://ncbi.nlm.nih.gov/pubmed/16906128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400784
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