Aβ42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

We have generated a novel transgenic mouse model on a C57BL/6J genetic background that coexpresses KM670/671NL mutated amyloid precursor protein and L166P mutated presenilin 1 under the control of a neuron-specific Thy1 promoter element (APPPS1 mice). Cerebral amyloidosis starts at 6–8 weeks and the...

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Bibliografische gegevens
Hoofdauteurs: Radde, Rebecca, Bolmont, Tristan, Kaeser, Stephan A, Coomaraswamy, Janaky, Lindau, Dennis, Stoltze, Lars, Calhoun, Michael E, Jäggi, Fabienne, Wolburg, Hartwig, Gengler, Simon, Haass, Christian, Ghetti, Bernardino, Czech, Christian, Hölscher, Christian, Mathews, Paul M, Jucker, Mathias
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2006
Onderwerpen:
Scientific Report
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1559665/
https://ncbi.nlm.nih.gov/pubmed/16906128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400784
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