Membrane-Anchored Aβ Accelerates Amyloid Formation and Exacerbates Amyloid-Associated Toxicity in Mice

Pathological, genetic, and biochemical hallmarks of Alzheimer's disease (AD) are linked to amyloid-β (Aβ) peptide aggregation. Especially misfolded Aβ(42) peptide is sufficient to promote amyloid plaque formation. However, the cellular compartment facilitating the conversion of monomeric Aβ to...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Nagarathinam, Amudha, Höflinger, Philip, Bühler, Anika, Schäfer, Claudia, McGovern, Gillian, Jeffrey, Martin, Staufenbiel, Matthias, Jucker, Mathias, Baumann, Frank
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2013
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618790/
https://ncbi.nlm.nih.gov/pubmed/24305824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2542-13.2013
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