IKBKE Protein Activates Akt Independent of Phosphatidylinositol 3-Kinase/PDK1/mTORC2 and the Pleckstrin Homology Domain to Sustain Malignant Transformation

Serine/threonine kinase Akt regulates key cellular processes such as cell growth, proliferation, and survival. Activation of Akt by mitogenic factor depends on phosphatidylinositol 3-kinase (PI3K). Here, we report that IKBKE (also known as IKKϵ and IKKi) activates Akt through a PI3K-independent path...

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Hlavní autoři: Guo, Jian-Ping, Coppola, Domenico, Cheng, Jin Q.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199486/
https://ncbi.nlm.nih.gov/pubmed/21908616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.287433
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