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Dissecting the functions of conserved prolines within transmembrane helices of the D2 dopamine receptor
G protein–coupled receptors (GPCRs) contain a number of conserved proline residues in their transmembrane helices, and it is generally assumed these play important functional and/or structural roles. Here we use unnatural amino acid mutagenesis, employing α–hydroxy acids and proline analogs, to exam...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3199346/ https://ncbi.nlm.nih.gov/pubmed/21776983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200153g |
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