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Introducing Human APOE into Aβ Transgenic Mouse Models
Apolipoprotein E (apoE) and apoE/amyloid-β (Aβ) transgenic (Tg) mouse models are critical to understanding apoE-isoform effects on Alzheimer's disease risk. Compared to wild type, apoE(−/−) mice exhibit neuronal deficits, similar to apoE4-Tg compared to apoE3-Tg mice, providing a model for Aβ-i...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
SAGE-Hindawi Access to Research
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3199079/ https://ncbi.nlm.nih.gov/pubmed/22028984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/810981 |
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