PTH Ablation Ameliorates the Anomalies of Fgf23-Deficient Mice by Suppressing the Elevated Vitamin D and Calcium Levels

Fibroblast growth factor 23 (FGF23) is a key regulator of mineral ion homeostasis. Genetic ablation of Fgf23 in mice leads to severe biochemical disorders including elevated serum 1,25-dihydroxyvitamin D [1,25(OH)(2)D], hypercalcemia, hyperphosphatemia, and marked decreased PTH levels. Because PTH s...

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Main Authors: Yuan, Quan, Sitara, Despina, Sato, Tadatoshi, Densmore, Michael, Saito, Hiroaki, Schüler, Christine, Erben, Reinhold G., Lanske, Beate
Formato: Artigo
Idioma:Inglês
Publicado: Endocrine Society 2011
Assuntos:
Calcium-Regulating Hormones
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199001/
https://ncbi.nlm.nih.gov/pubmed/21896668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-1113
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