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Genetic Ablation of Vitamin D Activation Pathway Reverses Biochemical and Skeletal Anomalies in Fgf-23-Null Animals

Fibroblast growth factor-23 (FGF-23) is one of the circulating phosphaturic factors associated with renal phosphate wasting. Fgf-23(−/−) animals show extremely high serum levels of phosphate and 1,25-dihydroxyvitamin D(3), along with abnormal bone mineralization and soft tissue calcifications. To de...

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Detalhes bibliográficos
Main Authors: Sitara, Despina, Razzaque, Mohammed S., St-Arnaud, René, Huang, Wei, Taguchi, Takashi, Erben, Reinhold G., Lanske, Beate
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1762489/
https://ncbi.nlm.nih.gov/pubmed/17148678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.060329
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