Transgenic Overexpression of the Transcription Factor Nkx6.1 in β-Cells of Mice Does Not Increase β-Cell Proliferation, β-Cell Mass, or Improve Glucose Clearance

The loss or dysfunction of the pancreatic endocrine β-cell results in diabetes. Recent innovative therapeutic approaches for diabetes aim to induce β-cell proliferation in vivo by pharmacological intervention. Based on the finding that overexpression of the transcription factor Nkx6.1 in islets in v...

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Detalhes bibliográficos
Main Authors: Schaffer, Ashleigh E., Yang, Almira J., Thorel, Fabrizio, Herrera, Pedro L., Sander, Maike
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2011
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198960/
https://ncbi.nlm.nih.gov/pubmed/21964593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-1010
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