Fluorous Iminoalditols: A New Family of Glycosidase Inhibitors and Pharmacological Chaperones

A collection of new reversible glycosidase inhibitors of the iminoalditol type featuring N-substituents containing perfluorinated regions has been prepared for evaluation of physicochemical, biochemical and diagnostic properties. The vast variety of feasible oligofluoro moieties allows for modular a...

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Detalhes bibliográficos
Main Authors: Schitter, Georg, Steiner, Andreas J., Pototschnig, Gerit, Scheucher, Elisabeth, Thonhofer, Martin, Tarling, Chris A., Withers, Stephen G., Fantur, Katrin, Paschke, Eduard, Mahuran, Don J., Rigat, Brigitte A., Tropak, Michael B., Illaszewicz, Carina, Saf, Robert, Stütz, Arnold E., Wrodnigg, Tanja M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198847/
https://ncbi.nlm.nih.gov/pubmed/20715263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201000192
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