A Drosophila genetic screen yields allelic series of core microRNA biogenesis factors and reveals post-developmental roles for microRNAs

Canonical animal microRNAs (miRNAs) are ∼22-nt regulatory RNAs generated by stepwise cleavage of primary hairpin transcripts by the Drosha and Dicer RNase III enzymes. We performed a genetic screen using an miRNA-repressed reporter in the Drosophila eye and recovered the first reported alleles of fl...

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Bibliographic Details
Main Authors: Smibert, Peter, Bejarano, Fernando, Wang, Dong, Garaulet, Daniel L., Yang, Jr-Shiuan, Martin, Raquel, Bortolamiol-Becet, Diane, Robine, Nicolas, Hiesinger, P. Robin, Lai, Eric C.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198593/
https://ncbi.nlm.nih.gov/pubmed/21947201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2983511
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