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Molecular Basis of Bcl-X(L)-p53 Interaction: Insights from Molecular Dynamics Simulations

Bcl-X(L), an antiapoptotic Bcl-2 family protein, plays a central role in the regulation of the apoptotic pathway. Heterodimerization of the antiapoptotic Bcl-2 family proteins with the proapoptotic family members such as Bad, Bak, Bim and Bid is a crucial step in the apoptotic regulation. In additio...

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Bibliografiska uppgifter
Huvudupphovsmän: Bharatham, Nagakumar, Chi, Seung-Wook, Yoon, Ho Sup
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2011
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198449/
https://ncbi.nlm.nih.gov/pubmed/22039431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026014
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