Targeted Inhibition of Calpain Reduces Myocardial Hypertrophy and Fibrosis in Mouse Models of Type 1 Diabetes

OBJECTIVE: Recently we have shown that calpain-1 activation contributes to cardiomyocyte apoptosis induced by hyperglycemia. This study was undertaken to investigate whether targeted disruption of calpain would reduce myocardial hypertrophy and fibrosis in mouse models of type 1 diabetes. RESEARCH D...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Li, Ying, Ma, Jian, Zhu, Huaqing, Singh, Manpreet, Hill, David, Greer, Peter A., Arnold, J. Malcolm, Abel, E. Dale, Peng, Tianqing
פורמט: Artigo
שפה:Inglês
יצא לאור: American Diabetes Association 2011
נושאים:
Complications
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198063/
https://ncbi.nlm.nih.gov/pubmed/21911754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1333
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