Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection

Streptococcus pneumoniae is a Gram-positive, extracellular bacterium that is responsible for significant mortality and morbidity worldwide. Pneumolysin (PLY), a cytolysin produced by all clinical isolates of the pneumococcus, is one of the most important virulence factors of this pathogen. We have p...

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Autores principales: Fang, Rendong, Tsuchiya, Kohsuke, Kawamura, Ikuo, Shen, Yanna, Hara, Hideki, Sakai, Shunsuke, Yamamoto, Takeshi, Fernandes-Alnemri, Teresa, Yang, Ruili, Hernandez-Cuellar, Eduardo, Dewamitta, Sita R., Xu, Yanting, Qu, Huixin, Alnemri, Emad S., Mitsuyama, Masao
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197964/
https://ncbi.nlm.nih.gov/pubmed/21957143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100381
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