The RD1 Locus in the Mycobacterium tuberculosis Genome Contributes to Activation of Caspase-1 via Induction of Potassium Ion Efflux in Infected Macrophages

A genomic locus called “region of difference 1” (RD1) in Mycobacterium tuberculosis has been shown to contribute to the generation of host protective immunity as well as to the virulence of the bacterium. To gain insight into the molecular mechanism, we investigated the difference in the cytokine-in...

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Detalhes bibliográficos
Main Authors: Kurenuma, Takeshi, Kawamura, Ikuo, Hara, Hideki, Uchiyama, Ryosuke, Daim, Sylvia, Dewamitta, Sita Ramyamali, Sakai, Shunsuke, Tsuchiya, Kohsuke, Nomura, Takamasa, Mitsuyama, Masao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737993/
https://ncbi.nlm.nih.gov/pubmed/19596775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00015-09
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