The RD1 Locus in the Mycobacterium tuberculosis Genome Contributes to Activation of Caspase-1 via Induction of Potassium Ion Efflux in Infected Macrophages

A genomic locus called “region of difference 1” (RD1) in Mycobacterium tuberculosis has been shown to contribute to the generation of host protective immunity as well as to the virulence of the bacterium. To gain insight into the molecular mechanism, we investigated the difference in the cytokine-in...

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Bibliographische Detailangaben
Hauptverfasser: Kurenuma, Takeshi, Kawamura, Ikuo, Hara, Hideki, Uchiyama, Ryosuke, Daim, Sylvia, Dewamitta, Sita Ramyamali, Sakai, Shunsuke, Tsuchiya, Kohsuke, Nomura, Takamasa, Mitsuyama, Masao
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2009
Schlagworte:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737993/
https://ncbi.nlm.nih.gov/pubmed/19596775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00015-09
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