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Phosphorylation of ASC acts as a molecular switch controlling the formation of speck-like aggregates and inflammasome activity
The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we show that Syk and JNK-dependent signaling pathways are required for caspase-1 activation via the ASC-dependent inflammasomes NLRP3 and AIM2. Inhibition of Syk or JNK abolished the formation of AS...
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| Publicat a: | Nat Immunol |
|---|---|
| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4813763/ https://ncbi.nlm.nih.gov/pubmed/24185614 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2749 |
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