Phosphorylation of ASC acts as a molecular switch controlling the formation of speck-like aggregates and inflammasome activity

The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we show that Syk and JNK-dependent signaling pathways are required for caspase-1 activation via the ASC-dependent inflammasomes NLRP3 and AIM2. Inhibition of Syk or JNK abolished the formation of AS...

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Bibliographic Details
Published in:Nat Immunol
Main Authors: Hara, Hideki, Tsuchiya, Kohsuke, Kawamura, Ikuo, Fang, Rendong, Hernandez-Cuellar, Eduardo, Shen, Yanna, Mizuguchi, Junichiro, Schweighoffer, Edina, Tybulewicz, Victor, Mitsuyama, Masao
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813763/
https://ncbi.nlm.nih.gov/pubmed/24185614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2749
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