Lataa...
Phosphorylation of ASC acts as a molecular switch controlling the formation of speck-like aggregates and inflammasome activity
The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we show that Syk and JNK-dependent signaling pathways are required for caspase-1 activation via the ASC-dependent inflammasomes NLRP3 and AIM2. Inhibition of Syk or JNK abolished the formation of AS...
Tallennettuna:
| Julkaisussa: | Nat Immunol |
|---|---|
| Päätekijät: | , , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2013
|
| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4813763/ https://ncbi.nlm.nih.gov/pubmed/24185614 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2749 |
| Tagit: |
Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!
|