Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury

We investigated whether plasma long-chain sphingoid base (LCSB) concentrations are altered by transient cardiac ischemia during percutaneous coronary intervention (PCI) in humans and examined the signaling through the sphingosine-1-phosphate (S1P) cascade as a mechanism underlying the S1P cardioprot...

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Autors principals: Egom, Emmanuel Eroume A., Mohamed, Tamer M. A., Mamas, Mamas A., Shi, Ying, Liu, Wei, Chirico, Debora, Stringer, Sally E., Ke, Yunbo, Shaheen, Mohamed, Wang, Tao, Chacko, Sanoj, Wang, Xin, Solaro, R. John, Fath-Ordoubadi, Farzin, Cartwright, Elizabeth J., Lei, Ming
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2011
Matèries:
Signaling and Stress Response
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197364/
https://ncbi.nlm.nih.gov/pubmed/21705677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01003.2010
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