Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury

We investigated whether plasma long-chain sphingoid base (LCSB) concentrations are altered by transient cardiac ischemia during percutaneous coronary intervention (PCI) in humans and examined the signaling through the sphingosine-1-phosphate (S1P) cascade as a mechanism underlying the S1P cardioprot...

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Autori principali: Egom, Emmanuel Eroume A., Mohamed, Tamer M. A., Mamas, Mamas A., Shi, Ying, Liu, Wei, Chirico, Debora, Stringer, Sally E., Ke, Yunbo, Shaheen, Mohamed, Wang, Tao, Chacko, Sanoj, Wang, Xin, Solaro, R. John, Fath-Ordoubadi, Farzin, Cartwright, Elizabeth J., Lei, Ming
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2011
Soggetti:
Signaling and Stress Response
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197364/
https://ncbi.nlm.nih.gov/pubmed/21705677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01003.2010
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