FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling

Recent studies demonstrated a role of sphingosine-1-phosphate (S1P) in the protection against the stress of ischemia/reperfusion (I/R) injury. In experiments reported here, we have investigated the signaling through the S1P cascade by FTY720, a sphingolipid drug candidate displaying structural simil...

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Main Authors: Egom, E. Eroume A, Ke, Yunbo, Musa, Hanny, Mohamed, Tamer M.A., Wang, Tao, Cartwright, Elizabeth, Solaro, R. John, Lei, Ming
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102016/
https://ncbi.nlm.nih.gov/pubmed/19852968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2009.10.009
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