Novel Phenazine 5,10-Dioxides Release (•)OH in Simulated Hypoxia and Induce Reduction of Tumour Volume In Vivo

Phenazine 5,10-dioxides (PDOs) are a new class of bioreductive cytotoxins, which could act towards tumours containing hypoxic regions. The PDOs selective-hypoxic bioreduction was probed in vitro; however, the mechanism of action has not been completely explained. Besides, PDOs in vivo antitumour act...

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Main Authors: Lavaggi, María L., Cabrera, Mauricio, Pintos, Cristina, Arredondo, Carolina, Pachón, Gisela, Rodríguez, Jorge, Raymondo, Stella, Pacheco, José Pedro, Cascante, Marta, Olea-Azar, Claudio, López de Ceráin, Adela, Monge, Antonio, Cerecetto, Hugo, González, Mercedes
Format: Artigo
Jezik:Inglês
Izdano: International Scholarly Research Network 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196961/
https://ncbi.nlm.nih.gov/pubmed/22084710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5402/2011/314209
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