New prodrugs and analogs of the phenazine 5,10-dioxide natural products iodinin and myxin promote selective cytotoxicity towards human acute myeloid leukemia cells

Novel chemotherapeutic strategies for acute myeloid leukemia (AML) treatment are called for. We have recently demonstrated that the phenazine 5,10-dioxide natural products iodinin (3) and myxin (4) exhibit potent and hypoxia-selective cell death on MOLM-13 human AML cells, and that the N-oxide funct...

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Detalhes bibliográficos
Publicado no:RSC Med Chem
Main Authors: Viktorsson, Elvar Örn, Aesoy, Reidun, Støa, Sindre, Lekve, Viola, Døskeland, Stein Ove, Herfindal, Lars, Rongved, Pål
Formato: Artigo
Idioma:Inglês
Publicado em: RSC 2021
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8152588/
https://ncbi.nlm.nih.gov/pubmed/34124675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1md00020a
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