DNA Strand Cleaving Properties and Hypoxia-Selective Cytotoxicity of 7-Chloro-2-thienylcarbonyl-3-trifluoromethylquinoxaline 1,4-Dioxide

The heterocyclic N-oxide, 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine, 1), shows promising antitumor activity in preclinical studies, but there is a continuing need to explore new compounds in this general structural category. In the work described here, we examined the properties of 7-chl...

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Hlavní autoři: Junnotula, Venkatraman, Rajapakse, Anuruddha, Arbillaga, Leire, de Cerain, Adela López, Solano, Beatriz, Villar, Raquel, Monge, Antonio, Gates, Kent S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268132/
https://ncbi.nlm.nih.gov/pubmed/20371184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.03.042
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