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DNA Strand Cleaving Properties and Hypoxia-Selective Cytotoxicity of 7-Chloro-2-thienylcarbonyl-3-trifluoromethylquinoxaline 1,4-Dioxide
The heterocyclic N-oxide, 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine, 1), shows promising antitumor activity in preclinical studies, but there is a continuing need to explore new compounds in this general structural category. In the work described here, we examined the properties of 7-chl...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3268132/ https://ncbi.nlm.nih.gov/pubmed/20371184 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.03.042 |
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