APOBEC1-Mediated Editing and Attenuation of Herpes Simplex Virus 1 DNA Indicate That Neurons Have an Antiviral Role during Herpes Simplex Encephalitis

APOBEC1 (A1) is a cytidine deaminase involved in the regulation of lipids in the small intestine. Herpes simplex virus 1 (HSV-1) is a ubiquitous pathogen that is capable of infecting neurons in the brain, causing encephalitis. Here, we show that A1 is induced during encephalitis in neurons of rats i...

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Detalhes bibliográficos
Main Authors: Gee, Peter, Ando, Yoshinori, Kitayama, Hiroko, Yamamoto, Seiji P., Kanemura, Yuka, Ebina, Hirotaka, Kawaguchi, Yasushi, Koyanagi, Yoshio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196441/
https://ncbi.nlm.nih.gov/pubmed/21775448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05288-11
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