Phosphorylation of Herpes Simplex Virus 1 dUTPase Regulates Viral Virulence and Genome Integrity by Compensating for Low Cellular dUTPase Activity in the Central Nervous System

A mutation in herpes simplex virus 1 dUTPase (vdUTPase), which precluded its phosphorylation at Ser-187, decreased viral neurovirulence and increased mutation frequency in progeny virus genomes in the brains of mice where endogenous cellular dUTPase activity was relatively low, and overexpression of...

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Bibliographic Details
Published in:J Virol
Main Authors: Kato, Akihisa, Arii, Jun, Koyanagi, Yoshio, Kawaguchi, Yasushi
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301107/
https://ncbi.nlm.nih.gov/pubmed/25320299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02497-14
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