Mutational Analysis of the Hypervariable Region of Hepatitis E Virus Reveals Its Involvement in the Efficiency of Viral RNA Replication

The RNA genome of the hepatitis E virus (HEV) contains a hypervariable region (HVR) in ORF1 that tolerates small deletions with respect to infectivity. To further investigate the role of the HVR in HEV replication, we constructed a panel of mutants with overlapping deletions in the N-terminal, centr...

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Main Authors: Pudupakam, R. S., Kenney, Scott P., Córdoba, Laura, Huang, Yao-Wei, Dryman, Barbara A., LeRoith, Tanya, Pierson, F. William, Meng, Xiang-Jin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196386/
https://ncbi.nlm.nih.gov/pubmed/21775444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00763-11
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