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Potential usage of proteasome inhibitor bortezomib (Velcade, PS-341) in the treatment of metastatic melanoma: basic and clinical aspects

Protein degradation by proteasome is essential to the regulation of important cellular functions including cell cycle progression, proliferation, differentiation and apoptosis. Abnormal proteasomal degradation of key regulatory proteins perturbs the normal dynamics of these cellular processes culmin...

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Autors principals: Shahshahan, Mohammad A, Beckley, Maureen N, Jazirehi, Ali R
Format: Artigo
Idioma:Inglês
Publicat: e-Century Publishing Corporation 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196288/
https://ncbi.nlm.nih.gov/pubmed/22016836
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