Phase 1 Study of Belinostat (PXD-101) and Bortezomib (Velcade, PS-341) in Patients with Relapsed or Refractory Acute Leukemia and Myelodysplastic Syndrome

We report the results of a phase 1 dose-escalation study of belinostat and bortezomib in adult patients with acute leukemia or MDS or CML with blast crisis. Thirty-eight patients received IV belinostat days 1-5 and 8-12 with IV bortezomib days 1, 4, 8, and 11 every 21 days. QTc prolongation was the...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Leuk Lymphoma
Main Authors: Holkova, Beata, Shafer, Danielle, Yazbeck, Victor, Dave, Sandeep, Bose, Prithviraj, Tombes, Mary Beth, Shrader, Ellen, Wan, Wen, Bandyopadhyay, Dipankar, Weir, Caryn, Collins, Elizabeth B., Garnett, Amanda, Kmieciak, Maciej, Roberts, John D., Garcia-Manero, Guillermo, Grant, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8106643/
https://ncbi.nlm.nih.gov/pubmed/33356689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10428194.2020.1861270
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados