Phase 1 Study of Belinostat (PXD-101) and Bortezomib (Velcade, PS-341) in Patients with Relapsed or Refractory Acute Leukemia and Myelodysplastic Syndrome

We report the results of a phase 1 dose-escalation study of belinostat and bortezomib in adult patients with acute leukemia or MDS or CML with blast crisis. Thirty-eight patients received IV belinostat days 1-5 and 8-12 with IV bortezomib days 1, 4, 8, and 11 every 21 days. QTc prolongation was the...

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Bibliografiske detaljer
Udgivet i:Leuk Lymphoma
Main Authors: Holkova, Beata, Shafer, Danielle, Yazbeck, Victor, Dave, Sandeep, Bose, Prithviraj, Tombes, Mary Beth, Shrader, Ellen, Wan, Wen, Bandyopadhyay, Dipankar, Weir, Caryn, Collins, Elizabeth B., Garnett, Amanda, Kmieciak, Maciej, Roberts, John D., Garcia-Manero, Guillermo, Grant, Steven
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8106643/
https://ncbi.nlm.nih.gov/pubmed/33356689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10428194.2020.1861270
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