Adipose-selective overexpression of ABHD5/CGI-58 does not increase lipolysis or protect against diet-induced obesity

Adipose triglyceride lipase (ATGL) catalyzes the first step of triacylglycerol hydrolysis in adipocytes. Abhydrolase domain 5 (ABHD5) increases ATGL activity by an unknown mechanism. Prior studies have suggested that the expression of ABHD5 is limiting for lipolysis in adipocytes, as addition of rec...

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Hauptverfasser: Caviglia, Jorge M., Betters, Jenna L., Dapito, Dianne-Helerie, Lord, Caleb C., Sullivan, Sean, Chua, Streamson, Yin, Terry, Sekowski, Anna, Mu, Haiyan, Shapiro, Lawrence, Brown, J. Mark, Brasaemle, Dawn L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196235/
https://ncbi.nlm.nih.gov/pubmed/21885429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M019117
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