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Insights into Folate/FAD-dependent tRNA Methyltransferase Mechanism: ROLE OF TWO HIGHLY CONSERVED CYSTEINES IN CATALYSIS
The flavoprotein TrmFO methylates specifically the C5 carbon of the highly conserved uridine 54 in tRNAs. Contrary to most methyltransferases, the 1- carbon unit transferred by TrmFO derives from 5,10-methylenetetrahydrofolate and not from S-adenosyl-l-methionine. The enzyme also employs the FAD hyd...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3196131/ https://ncbi.nlm.nih.gov/pubmed/21846722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.256966 |
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