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Cysteine of sequence motif VI is essential for nucleophilic catalysis by yeast tRNA m(5)C methyltransferase
Sequence comparison of several RNA m(5)C methyltransferases identifies two conserved cysteine residues that belong to signature motifs IV and VI of RNA and DNA methyltransferases. While the cysteine of motif IV is used as the nucleophilic catalyst by DNA m(5)C methyltransferases, this role is fulfil...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1894932/ https://ncbi.nlm.nih.gov/pubmed/17475914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.515707 |
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