Increased Bone Mass in Mice after Single Injection of Anti-receptor Activator of Nuclear Factor-κB Ligand-neutralizing Antibody: EVIDENCE FOR BONE ANABOLIC EFFECT OF PARATHYROID HORMONE IN MICE WITH FEW OSTEOCLASTS

Receptor activator of nuclear factor-κB ligand (RANKL) is a pivotal osteoclast differentiation factor. To investigate the effect of RANKL inhibition in normal mice, we prepared an anti-mouse RANKL-neutralizing monoclonal antibody (Mab, clone OYC1) and established a new mouse model with high bone mas...

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Autori principali: Furuya, Yuriko, Mori, Kaoru, Ninomiya, Tadashi, Tomimori, Yoshiya, Tanaka, Sakae, Takahashi, Naoyuki, Udagawa, Nobuyuki, Uchida, Kohji, Yasuda, Hisataka
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Metabolism
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196100/
https://ncbi.nlm.nih.gov/pubmed/21862583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.246280
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