Are Osteoclasts Needed for the Bone Anabolic Response to Parathyroid Hormone?: A STUDY OF INTERMITTENT PARATHYROID HORMONE WITH DENOSUMAB OR ALENDRONATE IN KNOCK-IN MICE EXPRESSING HUMANIZED RANKL

PTH stimulates osteoblastic cells to form new bone and to produce osteoblast-osteoclast coupling factors such as RANKL. Whether osteoclasts or their activity are needed for PTH anabolism remains uncertain. We treated ovariectomized huRANKL knock-in mice with a human RANKL inhibitor denosumab (DMAb),...

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Bibliografiske detaljer
Main Authors: Pierroz, Dominique D., Bonnet, Nicolas, Baldock, Paul A., Ominsky, Michael S., Stolina, Marina, Kostenuik, Paul J., Ferrari, Serge L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934681/
https://ncbi.nlm.nih.gov/pubmed/20558734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.101964
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