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Tumor Suppressor and Aging Biomarker p16(INK4a) Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype
Cellular senescence suppresses cancer by preventing the proliferation of cells that experience potentially oncogenic stimuli. Senescent cells often express p16(INK4a), a cyclin-dependent kinase inhibitor, tumor suppressor, and biomarker of aging, which renders the senescence growth arrest irreversib...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Biochemistry and Molecular Biology
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3196093/ https://ncbi.nlm.nih.gov/pubmed/21880712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.257071 |
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