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Forced Gating Motions by a Substituted Titratable Side Chain at the Bundle Crossing of a Potassium Channel

Numerous inwardly rectifying potassium (Kir) channels possess an aromatic residue in the helix bundle crossing region, forming the narrowest pore constriction in crystal structures. However, the role of the Kir channel bundle crossing as a functional gate remains uncertain. We report a unique phenot...

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Detalhes bibliográficos
Main Authors: Khurana, Anu, Shao, Evan S., Kim, Robin Y., Vilin, Yury Y., Huang, Xinyang, Yang, Runying, Kurata, Harley T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196073/
https://ncbi.nlm.nih.gov/pubmed/21878633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.249110
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