Mammalian Testis-determining Factor SRY and the Enigma of Inherited Human Sex Reversal: FRUSTRATED INDUCED FIT IN A BENT PROTEIN-DNA COMPLEX

Mammalian testis-determining factor SRY contains a high mobility group box, a conserved eukaryotic motif of DNA bending. Mutations in SRY cause XY gonadal dysgenesis and somatic sex reversal. Although such mutations usually arise de novo in spermatogenesis, some are inherited and so specify male dev...

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Bibliographische Detailangaben
Hauptverfasser: Phillips, Nelson B., Racca, Joseph, Chen, Yen-Shan, Singh, Rupinder, Jancso-Radek, Agnes, Radek, James T., Wickramasinghe, Nalinda P., Haas, Elisha, Weiss, Michael A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196072/
https://ncbi.nlm.nih.gov/pubmed/21849498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.260091
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