Structure-Function Relationships in Human Testis-determining Factor SRY: AN AROMATIC BUTTRESS UNDERLIES THE SPECIFIC DNA-BENDING SURFACE OF A HIGH MOBILITY GROUP (HMG) BOX

Human testis determination is initiated by SRY, a Y-encoded architectural transcription factor. Mutations in SRY cause 46 XY gonadal dysgenesis with female somatic phenotype (Swyer syndrome) and confer a high risk of malignancy (gonadoblastoma). Such mutations cluster in the SRY high mobility group...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Racca, Joseph D., Chen, Yen-Shan, Maloy, James D., Wickramasinghe, Nalinda, Phillips, Nelson B., Weiss, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239596/
https://ncbi.nlm.nih.gov/pubmed/25258310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.597526
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